KU-60019

KU-60019

Application

KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.

Biochem/physiol Actions

KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel.

Other Notes

KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Quality Level InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574885 KU-60019 white to beige 100 SCELLOWTHJGVIC-BGYRXZFFSA-N 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥97% (HPLC)
£533.46 (exc VAT) per 25MG
-
+
3574886 KU-60019 white to beige 100 SCELLOWTHJGVIC-BGYRXZFFSA-N 1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H SIGMA-ALDRICH −20°C DMSO: 20 mg/mL, clear powder ≥97% (HPLC)
£146.25 (exc VAT) per 5MG
-
+