KRN2

KRN2

Biochem/physiol Actions

KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS). It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.

KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576352 KRN2 faint yellow to dark orange SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear (warmed)
£501.43 (exc VAT) per 25MG
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3576353 KRN2 faint yellow to dark orange SIGMA-ALDRICH 2-8°C H2O: 2 mg/mL, clear (warmed)
£124.24 (exc VAT) per 5MG
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