KNK437

KNK437

Application

KNK437 has been used:as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cellsas an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cellsas a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions

KNK437is a benzylidene lactam compound.

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574301 KNK437 white to beige 100 SIGMA-ALDRICH room temp
£416.46 (exc VAT) per 25MG
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3574302 KNK437 white to beige 100 SIGMA-ALDRICH room temp
£136.50 (exc VAT) per 5MG
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