KL-2

KL-2

Biochem/physiol Actions

KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.

Disruptor of SEC (super elongation complex)

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576461 KL-2 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£501.43 (exc VAT) per 25MG
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3576462 KL-2 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£124.24 (exc VAT) per 5MG
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