Keratin from human epidermis, aqueous solution

Keratin from human epidermis, aqueous solution

Application

Keratin from human epidermis has been used:as an analyte and a cross-reactant in the antibody-immobilized chip for testing selectivity coefficients as a standard in extracellular matrix (ECM) protein in in vitro protein degradation assays.asa a standard in enzyme linked immunosorbent assay (ELISA)

Biochem/physiol Actions

Keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Some keratins also have regulatory functions and are involved in intracellular signaling pathways, e.g. protection from stress, wound healing, and apoptosis. This diverse group of cytoskeletal scaffolding proteins form intermediate filament networks which provide structural support to keratinocytes that maintain the integrity of the skin. Expression of keratin genes is usually regulated by differentiation of the epidermal cells within the stratifying squamous epithelium.

General description

Keratins are characteristic intermediate filament proteins of the epithelia. In human, keratin is classified into type I and type II. About 54 genes encodes for the keratin protein. The keratin 1 (KRT1) gene is mapped to human chromosome 12q13.13. It is the primary component of hair, skin and nails.

Physical form

Solution in 8 M urea, 50 mM Tris, 0.1 M β-mercaptoethanol and 0.1% sodium azide, pH 8.4

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Code Description Quality Level Manufacturer Technique(s) Storage Temp. Form Assay Price Quantity
3591580 Keratin from human epidermis, aqueous solution 200 SIGMA-ALDRICH ELISA: suitable 2-8°C urea solution ≥90% (SDS-PAGE)
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3591581 Keratin from human epidermis, aqueous solution 200 SIGMA-ALDRICH ELISA: suitable 2-8°C urea solution ≥90% (SDS-PAGE)
£217.50 (exc VAT) per 1MG
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3591582 Keratin from human epidermis, aqueous solution 200 SIGMA-ALDRICH ELISA: suitable 2-8°C urea solution ≥90% (SDS-PAGE)
£1,031.25 (exc VAT) per 5MG
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