JNJ0966

JNJ0966

Biochem/physiol Actions

JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears that JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogen, and has no effect on MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 catalytic activity.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576538 JNJ0966 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£435.96 (exc VAT) per EACH
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3576539 JNJ0966 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£134.97 (exc VAT) per EACH
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