JNJ-47965567

JNJ-47965567

Biochem/physiol Actions

JNJ-47965567 is a potent P2X7 antagonist with high affinity for the rat receptor (pKi = 8.7). It is centrally available after systemic injection with a superior brain:plasma distribution compared to other available P2X7 antagonists. JNJ-47965567 was shown to suppress epileptic seizures in a mouse model of epilepsy. It appears to have a disease modifying effect since spontaneous seizure rates did not increase once treatment with JNJ-477965567 was stopped.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575293 JNJ-47965567 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£604.50 (exc VAT) per 25MG
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3575294 JNJ-47965567 white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£149.04 (exc VAT) per 5MG
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