IMR-1

IMR-1

Application

Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells.

Biochem/physiol Actions

IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575413 IMR-1 white to beige 100 SIGMA-ALDRICH 2-8°C
£536.25 (exc VAT) per 25MG
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3575414 IMR-1 white to beige 100 SIGMA-ALDRICH 2-8°C
£131.76 (exc VAT) per 5MG
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