ILOPERIDONE

ILOPERIDONE

Biochem/physiol Actions

Iloperidone is an atypical antipsychotic, a combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Iloperidone targets a selective set of dopamine, serotonin and also norepinephrine receptor subtypes. Like similar atypical antipsychotics, Iloperidone has higher affinity for the 5-HT2A receptor (Ki ﹤ 10 nM) than for the D2 receptor (Ki = 10–100) nM). Iloperidone has high affinity for dopamine D3 (Ki ﹤ 10 nM) and lower affinity for other serotonin or dopamine subtypes. Unlike most atypical antipsychotics, Iloperidone also has high affinity for norepinephrine alpha1 receptors (Ki ﹤ 10 nM) which may contribute to the drug’;s efficacy on mood and cognition.

Packaging

10, 50 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575034 ILOPERIDONE white to beige 100 XMXHEBAFVSFQEX-UHFFFAOYSA-N 1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 SIGMA-ALDRICH DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£122.85 (exc VAT) per 10MG
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3575035 ILOPERIDONE white to beige 100 XMXHEBAFVSFQEX-UHFFFAOYSA-N 1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3 SIGMA-ALDRICH DMSO: 5 mg/mL, clear powder ≥98% (HPLC)
£500.04 (exc VAT) per 50MG
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