ICA-121431

ICA-121431

Biochem/physiol Actions

ICA-121431 [2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide, a small molecule inhibitor, targets the extracellular amino acids in S2 and S3 in VSDIV (domain IV voltage sensor), which is essential for Hm1a efficacy. In humans, ICA-121431 blocks TTX-sensitive Nav1.3 sodium channels upregulated in HEK-293 cells.

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574381 ICA-121431 white to beige 100 SIGMA-ALDRICH room temp DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£551.57 (exc VAT) per 25MG
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3574382 ICA-121431 white to beige 100 SIGMA-ALDRICH room temp DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£164.36 (exc VAT) per 5MG
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