HTH-01-015

HTH-01-015

Biochem/physiol Actions

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) tumour suppressor kinase and involved in development and proliferation. HTH-01-015 has an IC50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with HTH-01-015 was found to suppress proliferation, restricting cells from entering into mitosis.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574918 HTH-01-015 white to light brown 100 CHSDJDLAKKAWCI-UHFFFAOYSA-N 1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7,12-15,20,27H,8-11H2,1-3H3, SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£454.07 (exc VAT) per 25MG
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3574919 HTH-01-015 white to light brown 100 CHSDJDLAKKAWCI-UHFFFAOYSA-N 1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7,12-15,20,27H,8-11H2,1-3H3, SIGMA-ALDRICH DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£167.14 (exc VAT) per 5MG
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