HLY78

HLY78

Biochem/physiol Actions

HLY78 is an activator of the Wnt/β-Catenin signaling pathway. HLY78 acts upstream of β-catenin synergistically with Wnt. It is believed to bind at a cavity at the dimeric interface of the Axin DIX domain, causing a conformational change of Axin to an active state, potentiating Axin–LRP6 association and promoting Wnt signaling transduction. There are several Wnt inhibitors used to study their potential in cancer therapy but few small molecules that activate the Wnt pathway. In Zebrafish, HLY78 increased the expression of the hematopoietic stem cell (HSC) transcription factors runx1 and cmyb, showing that it might be useful in HSC expansion, which could be important in transplantation and recovery after injury.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574149 HLY78 white to beige 100 SIGMA-ALDRICH 2-8°C
£554.36 (exc VAT) per 25MG
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3574150 HLY78 white to beige 100 SIGMA-ALDRICH 2-8°C
£109.06 (exc VAT) per 5MG
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