HET0016

HET0016

Biochem/physiol Actions

HET0016 is a potent and selective inhibitor against cytochrome P450 (CYP450) ω-hydroxylases (human CYP4A11/4A22/4F2/4F3, rat CYP4A1/4A2/4A3/4A8)-mediated 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis (IC50 = 8.9/35 nM using human/rat renal microsomes), exhibiting much reduced potency against epoxyeicosatrienoic acids (EETs) biosynthesis (IC50 = 2.8 μM/rat microsome) or the enzyme activities of CYP2C9/2D6/3A4 and COX (IC50 = 3.3/83.9/71 μM and 2.3 μM). HET0016 is widely employed both in cultures (1-10 μM) and in aminals in vivo (1-10 mg/kg via i.v., i.m., i.p. or s.c.) for probing 20-HETE-dependent physiological and pathological processes.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576285 HET0016 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£327.32 (exc VAT) per 25MG
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3576286 HET0016 white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£80.51 (exc VAT) per 5MG
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