Heparinase I and III Blend from Flavobacterium heparinum,

Heparinase I and III Blend from Flavobacterium heparinum,

Application

Heparinase I and III Blend from Flavobacterium heparinum has been used in:the digestion of heparan sulfate from ovine vitreous human embryonic kidney cells glycosaminoglycans from arterial tissuesP0 retinaedigestion

Biochem/physiol Actions

Heparin-degrading lyase that recognizes heparin sulfate proteoglycan as its primary substrate.

Heparinase I and III plays vital role in various biological processes: modulate cell-growth factor interactions, cell-lipoprotein interactions, neovascularization. It cleaves highly sulphated polysaccharide chains in presence of 2-O-sulfated ?-L-idopyranosyluronic acid and ?-D-glucopyranosyluronic acid residues of polysaccharides.

General description

Heparinase is an inducible, non-extracellular heparin-degrading enzyme. Three types of heparinises are produced by Flavobacterium heparinum and contains specific sequences of heparin.

Other Notes

Enzyme Commission Numbers: 4.2.2.7 Hep I and 4.2.2.8 Hep III

Packaging

Sold on the basis of Heparinase I units

Unit Definition

One unit will form 0.1 micromole of unsaturated uronic acid per hour at 7.5 at 25 degrees C using Heparin, Sodium as substrate for heparinase I.One unit will form 0.1 micromole of unsaturated uronic acid per hour at 7.5 at 25 degrees C using bovine kidney Heparan, Sulfate as substrate for heparinase III.One unit will form 0.1 µmole of unsaturated uronic acid per hr at pH 7.5 at 25 °C. One International Unit (I.U.) is equivalent to approx. 600 Sigma units. Package sizes are sold in Sigma units.

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Code Description Quality Level Manufacturer Storage Temp. Form Price Quantity
3579691 Heparinase I and III Blend from Flavobacterium heparinum, 200 SIGMA-ALDRICH −20°C lyophilized powder
£632.36 (exc VAT) per EACH
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3579692 Heparinase I and III Blend from Flavobacterium heparinum, 200 SIGMA-ALDRICH −20°C lyophilized powder
Click Add to Quote for price and delivery
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3579693 Heparinase I and III Blend from Flavobacterium heparinum, 200 SIGMA-ALDRICH −20°C lyophilized powder
£324.54 (exc VAT) per EACH
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