H-151

H-151

Biochem/physiol Actions

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576310 H-151 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£486.11 (exc VAT) per EACH
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3576311 H-151 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£119.93 (exc VAT) per EACH
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