GSK2193874

GSK2193874

Application

GSK2193874 has been used as a transient receptor potential vanilloid 4 (TRPV4) antagonist:to study its effects on GSK101-induced colon contractions in miceto study its effects on murine compact bone-derived osteoblasts(CB-OB)to study its effects on lung injury post-lipopolysaccharide (LPS) in mice

Biochem/physiol Actions

GSK2193874 is a very potent, specific antagonist of TRPV4 ion channels (IC50 = 50 nM). Lung edema caused by high pulmonary venous pressure (PVP) is driven by TRPV4 activity. GSK2193874 blocks TRPV4-mediated calcium influx in cells expressing native and recombinant TRPV4, and inhibits vascular permeability and lung edema in isolated rodent and canine lungs subjected to high PVP. The compound also resolves pulmonary edema in murine myocardial infarction model.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574269 GSK2193874 white to beige 100 SIGMA-ALDRICH room temp
£552.96 (exc VAT) per 25MG
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3574270 GSK2193874 white to beige 100 SIGMA-ALDRICH room temp
£183.86 (exc VAT) per 5MG
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