GSK1702934A

GSK1702934A

Biochem/physiol Actions

GSK1702934A (GSK-2934A) is a direct activator of TRPC3 and TRPC6 ion channels with selectivity for TRPC3. In HEK293 kidney cells transduced with recombinant human TRPC3 or TRPC6, GSK1702934A activated current with an EC50 of ~ 80 nM for TRPC3 vs. 440 nM for TRPC6. It does not activate TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at concentrations ﹤10 µM. GSK1702934A has been used to study TRPC3 channels in the heart, exhibiting pro-arrhythmic, and inotropic actions in isolated Langendorff hearts from TRPC3-overexpressing mice.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576143 GSK1702934A white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£565.50 (exc VAT) per 25MG
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3576144 GSK1702934A white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£139.29 (exc VAT) per 5MG
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