Glucagon-Like Peptide I Amide Fragment 7-36 human, >=97% (HPLC), powder

Glucagon-Like Peptide I Amide Fragment 7-36 human, >=97% (HPLC), powder

Amino Acid Sequence

His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Application

Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist: in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activityto pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeletonto test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries

Glucagon-Like Peptide I Amide Fragment 7-36 human has been used as a supplement in DMEM (Dulbeccos’;) medium for the culture of 3T3-L1 adipocytes to study the relation between adipose tissue GLP-1 Receptor and obesity and insulin resistance.

Biochem/physiol Actions

GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus.

General description

Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Code Description Quality Level InChI key InChI Manufacturer Storage Temp. Form Assay Price Quantity
3591362 Glucagon-Like Peptide I Amide Fragment 7-36 human, >=97% (HPLC), powder 200 DTHNMHAUYICORS-KTKZVXAJSA-N 1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(2 SIGMA-ALDRICH
£256.29 (exc VAT) per EACH
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3591363 Glucagon-Like Peptide I Amide Fragment 7-36 human, >=97% (HPLC), powder 200 DTHNMHAUYICORS-KTKZVXAJSA-N 1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(2 SIGMA-ALDRICH
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