Glucagon, >=95% (HPLC), powder, synthetic

Glucagon, >=95% (HPLC), powder, synthetic

Amino Acid Sequence

His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr

Application

Glucagon (GCG) has been used:as a component of hormone stock solution for preserving full biological activity of heart tissues obtained from male Sprague-Dawley ratsas an infusion in phases II and III fasting king penguins to study the various lipolytic, metabolic, and hormonal responsesfor the stumulation of PGC-1? expression in hepatocytes

Biochem/physiol Actions

The paired box 6 (PAX6) regulates the expression of glucagon. High levels of glucagon referred to as hyperglucagonemialeads to a high risk of diabetes and is associated with pancreatic neuroendocrine tumors. Defective glucagon hypersecretion is regarded as an etiopathogenic factor.

Glucagon (GCG) produces elevation in contractility and the frequency of contraction in heart muscles. It activates PI3K (phosphoinositide 3-kinase) and thus, elevates glucose utilization by heart muscles. In multiple mammals, though not humans, this peptide induces lipolysis, and is the major lipolytic hormone in birds. It also induces gluconeogenesis and glycogenolysis in mammals and birds.

Components

H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH.xHCl

General description

Glucagon (GCG) peptide is secreted in response to insulin from pancreatic islets ?-cells.

Glucagon is synthesized from proglucagon and is 29-amino acid peptide hormone. Proglucagon gene is mapped to human chromosome 2q24.2.

Other Notes

Lyophilized from 0.1% TFA in H2O

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Code Description Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3591275 Glucagon, >=95% (HPLC), powder, synthetic 300 RKGLLHCSSVJTAN-YYICOITRSA-N 1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64- SIGMA-ALDRICH powder ≥95% (HPLC)
£259.07 (exc VAT) per EACH
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3591276 Glucagon, >=95% (HPLC), powder, synthetic 300 RKGLLHCSSVJTAN-YYICOITRSA-N 1S/C153H225N43O49S.ClH/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64- SIGMA-ALDRICH powder ≥95% (HPLC)
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