G3335

G3335

Biochem/physiol Actions

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 µM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 µM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

Packaging

50, 250 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Form Assay Price Quantity
3574924 G3335 white to off-white 100 SIGMA-ALDRICH −20°C
£472.18 (exc VAT) per 250MG
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3574925 G3335 white to off-white 100 SIGMA-ALDRICH −20°C
£146.25 (exc VAT) per 50MG
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