FPH1

FPH1

Biochem/physiol Actions

FPH1 (BRD-6125) induces functional proliferation of primary human hepatocytes in vitro. Human induced pluripotent stem (iPS) cells can be differentiated toward hepatocyte-like (iHep) cells, but replication is not great, and cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. FPH1 induced hepatocyte colonies were used in conjunction with FH1 (BRD-K4477) to induce a more mature phenotype. Cultures treated with both FH1 and FPH1 contained larger colonies of hepatocyte-like (iHep) cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574143 FPH1 white to beige 100 SIGMA-ALDRICH −20°C
£554.36 (exc VAT) per 25MG
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3574144 FPH1 white to beige 100 SIGMA-ALDRICH −20°C
£136.50 (exc VAT) per 5MG
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