FLUORIZOLINE

FLUORIZOLINE

Biochem/physiol Actions

Fluorizoline is a prohibitin (PHB) 1/2-binding diaryl trifluorothiazoline compound that induces p53-independent apoptosis in various cancer cultures (IC50 from 1.6 µM/Bx-PC3 to 9.4 µM/JeKo 1; 24 h) and upregulates proapoptotic Noxa and Bim mRNAs in wild-type, but not PHBs-depleted MEFs. Box(-/-)/Bak(-/-) or Noxa(-/-)/Bim(-/-) MEFs as well as BAX/BAK- or NOXA-downregulated HeLa cells are resistant to fluorizoline-induced apoptosis. Fluorizoline treatment is shown to prevent active RAS-CRAF interaction and downstream MEK1/2 activation following EGF stimulation in HeLa cells (10 µM).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576232 FLUORIZOLINE white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£546.00 (exc VAT) per 25MG
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3576233 FLUORIZOLINE white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£134.97 (exc VAT) per 5MG
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