FEXARAMINE

FEXARAMINE

Application

Fexaramine has been used to study its action on RANKL (receptor activator of nuclear factor-?B ligand)-induced osteoclastogenesis in mouse model.

Biochem/physiol Actions

Fexaramine is a potent and selective agonist of the bile acid sensor farnesoid X receptor (FXR) in the gut with an EC50 of 25 nM and no activity found for other nuclear receptors. Fexaramine induces enteric fibroblast growth factor 15 (FGF15), causing alterations in bile acid composition without activating FXR target genes in the liver. In mouse studies, fexaramine enhanced thermogenesis and browning of white adipose tissue while reducing diet-induced weight gain, body-wide inflammation and hepatic glucose production. Fexaramine also improved insulin responsiveness.

Fexaramine might regulate lipid and glucose metabolism and can serve as a therapeutic target in the treatment of fatty liver disease, type 2 diabetes and obesity. Fexaramine might mediate cholesterol homeostasis and promotes osteoblast differentiation and suppresses differentiation of osteoclast.

General description

Fexaramine belongs to the nuclear hormone receptor family.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574844 FEXARAMINE white to beige 100 VLQTUNDJHLEFEQ-KGENOOAVSA-N 1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£668.57 (exc VAT) per 25MG
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3574845 FEXARAMINE white to beige 100 VLQTUNDJHLEFEQ-KGENOOAVSA-N 1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1 SIGMA-ALDRICH DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£168.54 (exc VAT) per 5MG
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