EZATIOSTAT

EZATIOSTAT

Application

Ezatiostat has been used as glutathione S-transferase P1 (GSTP1) inhibitor:to study its effects on peroxiredoxin 6 (PRDX6) inhibition in neonatal rat testicular gonocytesfor the incubation of bronchial epithelial cells in proteolysis assayto study its effects on the cystine-glutamate antiporter xCT (SLC7A11) expression in tumor cells

Biochem/physiol Actions

Ezatiostat is an inhibitor of glutathione S-transferase P1-1 (GSTP1-1) with hematopoiesis-stimulating activity. After intracellular de-esterification, the active form of ezatiostat binds to and inhibits GST P1-1, leading to activation of Jun kinase (JNK), a key regulator of cellular growth and differentiation of blood precursor cells, thereby restoring JNK and MAPK pathway activities and promoting MAPK-mediated cellular proliferation and differentiation. Ezatiostat promotes the proliferation and maturation of hematopoietic precursor cells, granulocytes, monocytes, erythrocytes and platelets. Ezatiostat has recently been given orphan drug designation for it for the treatment of myelodysplastic syndrome.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574441 EZATIOSTAT white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£618.43 (exc VAT) per 25MG
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3574442 EZATIOSTAT white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 5 mg/mL, clear (warmed) powder ≥98% (HPLC)
£153.21 (exc VAT) per 5MG
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