EU1794-4

EU1794-4

Biochem/physiol Actions

EU1794-4 is an N-methyl-d-aspartate (NMDA) receptor (NMDAR) allosteric modulator that prevents large degree receptor activation in the presence of high level Glu/Gly (IC50/Emax = 2.2 µM/32%/GluN2A, 2.6 µM/67%/GluN2B, 0.42 µM/52%/GluN2C, 0.36 µM/51%/GluN2D with Glu/Gly = ECmax = 100/30 µM using xenopus oocytes co-expressing rat GluN1 and respective GluN2 subtype), while augmenting receptor activation at low level Glu/Gly (EC50/Emax = 3.9 µM/500%/GluN2A, 4.3 µM/210%/GluN2B, 15 µM/220%/GluN2C with Glu/Gly = 1/0.3 µM; 14 µM/540%/GluN2D with Glu/Gly = 300/9 nM).

EU1794-4 consists of an ethyl ester and lacks a methyl substituent on the tetrahydrobenzothiophene core.

No detailed specifications are available for this product.

There are no downloads for this product.

Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576281 EU1794-4 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£360.05 (exc VAT) per 25MG
-
+
3576282 EU1794-4 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£89.14 (exc VAT) per 5MG
-
+