EU1794-27

EU1794-27

Biochem/physiol Actions

NMDA receptor is important for glutamate neurotransmission. It is associated with learning ability and memory. NMDA receptor possesses two different subunits NMDAR1 and NMDAR2. Tyrosine phosphorylation controls the actions of NMDA receptors. It is also known to influence neuronal function.

EU1794-27 is an N-methyl-d-aspartate (NMDA) receptor (NMDAR) positive allosteric modulator (PAM) toward GluN2A/B/C subtypes (EC50/Emax = 1.4 µM/130%/GluN2B, 2.8 µM/230%/GluN2C, 2.4 µM/250%/GluN2D with Glu/Gly = ECmax = 100/30 µM using xenopus oocytes co-expressing rat GluN1 and respective GluN2 subtype; EC50/Emax = 6.3 µM/400%/GluN2B, 5.0 µM/680%/GluN2C with Glu/Gly = 1/0.3 µM &,;2.4 µM/580%/GluN2D with Glu/Gly = 0.6/0.2 µM), while it exhibits Glu/Gly level-dependent GluN1-GluN2A-modulating activities (EC50/Emax = 7.4 µM/52%/GluN2A with Glu/Gly = 100/30 µM; 8.1 µM/340% with Glu/Gly = 2/0.6 µM).

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576283 EU1794-27 white to light brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£360.05 (exc VAT) per 25MG
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3576284 EU1794-27 white to light brown SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£89.14 (exc VAT) per 5MG
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