ETAKG

ETAKG

Biochem/physiol Actions

ETaKG is a cell-permeable, aqueous stable, bioavailable, non-toxic A-ketoglutarate/2-oxoglutarate (A-KG/2-OG) diester derivative that readily undergoes hydrolysis by cytosolic esterases to A-KG. The monoester analog, TaKG is also membrane permeant. ETaKG elevates intracellular [A-KG] by ~15-fold in a prologned fashion, destabilizes HIF-1A/2A and reactivates prolyl hydroxylases (PHDs) in hypoxic HCT116, A431 and RPE cells at 2 mM. Further, shown to selectively trigger PHD-dependent cell death in hypoxic cells and decreases cellular [ATP] and glucose uptake. ETaKG has shown to reduce glucose metabolism, elevate [A-KG] levels and suppress A375 xenograft tumor growth (750 mg/kg of mice, p.o., q.d., 14 days). Also, induces mTORC1 lysosomal translocation and stimulates mTORC1 activity in the absence of glutaminolysis in U2OS cells.

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Code Description Colour Quality Level Manufacturer Storage Temp. Form Assay Price Quantity
3575334 ETAKG colorless to light yellow 100 SIGMA-ALDRICH 2-8°C
£536.25 (exc VAT) per 25MG
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3575335 ETAKG colorless to light yellow 100 SIGMA-ALDRICH 2-8°C
£150.43 (exc VAT) per 5MG
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