ERLOTINIB HYDROCHLORIDE

ERLOTINIB HYDROCHLORIDE

Application

Erlotinib hydrochloride has been used to activate mitochondrial fragmentation in a human PANC-1 pancreatic cancer cell line.

Biochem/physiol Actions

Erlotinib hydrochloride is an inhibitor of the receptor tyrosine kinase EGFR (epidermal growth factor receptor). It is used clinically for the treatment of non-small cell lung cancer (NSCLC) and in combination for metastatic pancreatic cancer.

General description

Erlotinib hydrochloride is an antineoplastic drug. It regulates mechanistic target of rapamycin (mTOR) inhibition, epidermal growth factor receptor down-regulation and epidermal interstitial transformation (EMT) suppression.

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Code Description Colour InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575889 ERLOTINIB HYDROCHLORIDE white to beige GTTBEUCJPZQMDZ-UHFFFAOYSA-N 1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£178.29 (exc VAT) per 100MG
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3575890 ERLOTINIB HYDROCHLORIDE white to beige GTTBEUCJPZQMDZ-UHFFFAOYSA-N 1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£88.17 (exc VAT) per 50MG
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