ERDOSTEINE

ERDOSTEINE

Application

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1?-stimulated inflammation in rat chondrocytes in osteoarthritis models.

Biochem/physiol Actions

Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

General description

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.

Packaging

50, 250 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575036 ERDOSTEINE white to beige 100 QGFORSXNKQLDNO-UHFFFAOYSA-N 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12) SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£388.61 (exc VAT) per 250MG
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3575037 ERDOSTEINE white to beige 100 QGFORSXNKQLDNO-UHFFFAOYSA-N 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12) SIGMA-ALDRICH 2-8°C DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£124.94 (exc VAT) per 50MG
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