EF5 98% HPLC

EF5 98% HPLC

Biochem/physiol Actions

EF5 is a 2-nitroimidazole-based hypoxia marker corresponding to a pentafluorinated derivative of the hypoxic cell-radiation sensitizer etanidazole. Under low oxygen (hypoxic) condition, reductive activation of its 2-nitroimidazole moiety leads to enhanced EF5 adduct formation with protein thiols and reduced glutathione. The pentafluorination derivatization substantially decreases the proportion of low molecular weight hydrolytic fragmentation of the adducts, making EF5 superior to etanidazole when utilized as a hypoxia marker by immunohistological staining.

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575624 EF5 98% HPLC white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£515.36 (exc VAT) per 25MG
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3575625 EF5 98% HPLC white to beige 100 SIGMA-ALDRICH 2-8°C DMSO: 10 mg/mL, clear powder ≥98% (HPLC)
£160.18 (exc VAT) per 5MG
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