EACT

EACT

Biochem/physiol Actions

Eact activates the Calcium-activated Chloride channel (CaCC) TMEM16A CaCC. Eact stimulates CaCC conductance in salivary gland cells and submucosal airway epithelial cells. The compound Eact also stimulates submucosal gland secretion in human bronchial tissue and smooth muscle contraction in mouse intestine.

In rat arterial myocytes, Eact [3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide] helps to activate chloride current and prevents estradiol synthesis in cultured mouse granulosa cells. It is a small molecule activator of TMEM16A (transmembrane member 16A), that activates TRPV1 (transient receptor potential cation channel subfamily V member 1) and generates pain and itch related symptoms. Eact also initiates endogenous TRPV1 expressed by DRG (dorsal root ganglion) neurons.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574540 EACT white to beige 100 ZUXNHFFVQWADJL-UHFFFAOYSA-N 1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£438.75 (exc VAT) per 25MG
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3574541 EACT white to beige 100 ZUXNHFFVQWADJL-UHFFFAOYSA-N 1S/C22H24N2O5S/c1-26-11-10-24(22-23-17(14-30-22)15-8-6-5-7-9-15)21(25)16-12-18(27-2)20(29-4)19(13-16)28-3/h5-9,12-14H,10-11H2,1-4H3 SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£157.39 (exc VAT) per 5MG
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