DS44170716

DS44170716

Biochem/physiol Actions

DS44170716 is an inhibitor of Ca2+-induced mitochondrial permeability transition. It has a different mechanism of action from cyclosporin A that is not dependent on PPIF, a peptidyl-prolyl cis-trans isomerase associated with the mitochondrial permeability transition pore (MPTP). Instead DS44170716 blocks Ca2+ flux into the mitochondria by decreasing mitochondrial membrane potential and inhibits enzyme activities of mitochondrial respiratory chain complex III, IV and V. It showed a similar potent protective effect against Ca2+-induced death in human liver cells as Cyclosporin A.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575701 DS44170716 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£490.29 (exc VAT) per 25MG
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3575702 DS44170716 white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear (warmed) powder ≥98% (HPLC)
£121.32 (exc VAT) per 5MG
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