DS-437

DS-437

Application

DS-437 has been used as an inhibitor of protein arginine methyltransferase 5 (PRMT5) to study its effect on forkhead box P3 (FOXP3) methylation and regulatory T cells (Tregs) function in 293T cells.

Biochem/physiol Actions

DS-437 inhibits regulatory T cells (Tregs) function and methylation of forkhead box P3 (FOXP3) in 293T cells. DS-437 in combination with anti-p185erbB2/neu antibody 4D5 reduces tumor growth in CT26HER2 tumor-bearing mice.

DS-437 is an analog of S-adenosyl methionine (SAM ), which inhibits protein arginine methyltransferases PRMT5 and PRMT7 (IC50 5.9 and 6 µM) with little interaction against a panel of 30 other human methyltransferases.

Other Notes

DS-437 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the DS-437 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

No detailed specifications are available for this product.

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3575016 DS-437 white to beige 100 CACMCLIHCDTJHL-XNZUMOJTSA-N 1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10
£438.75 (exc VAT) per 25MG
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3575017 DS-437 white to beige 100 CACMCLIHCDTJHL-XNZUMOJTSA-N 1S/C15H23N7O4S/c1-2-17-15(25)18-3-4-27-5-8-10(23)11(24)14(26-8)22-7-21-9-12(16)19-6-20-13(9)22/h6-8,10-11,14,23-24H,2-5H2,1H3,(H2,16,19,20)(H2,17,18,25)/t8-,10
£124.94 (exc VAT) per 5MG
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