DL-?-Hydroxybutyric acid sodium salt has been used:as a standard for quantifying blood plasma and milk ?-hydroxybutyric acid in Danish Jersey cowsto investigate its anticonvulsant effects in epilepsy induced ratsto induce hyperketonemia in Holstein dairy cows
Biochem/physiol Actions
?-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD+, measured fluorimetrically. A high plasma level of ?-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. ?-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson?s disease model. ?-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).