DIM-C-PPHCO2ME

DIM-C-PPHCO2ME

Biochem/physiol Actions

DIM-C-pPhCO2Me is also known as 1,1-bis(3?-indolyl)-1-(p-carboxymethylphenyl)methane. In pancreatic and colon cancer cells, DIM-C-pPhCO2Me plays an inhibitory role on cell migration. DIM-C-pPhCO2Me prevents the action of mechanistic target of rapamycin (mTOR) and reduces the multiplication and survival of cancer cells. It stimulates reactive oxygen species (ROS) in various cancer cell lines.

DIM-C-pPhCO2Me is a NR4A1 (Nur77) antagonist that exhibit potent anticancer activity in pancreatic, colon, breast, kidney, and rhabdomyosarcoma cells. DIM-C-pPhCO2Me decreases expression of PAX3-FOXO1A and β1-integrin proteins in Rh30 rhabdomyosarcoma and MDA-MB-231 breast cancer cells. DIM-C-pPhCO2Me inhibits migration of Rh30 and MDA-MB-231 cancer cells.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3575648 DIM-C-PPHCO2ME pink to light red SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£561.32 (exc VAT) per 25MG
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3575649 DIM-C-PPHCO2ME pink to light red SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£174.11 (exc VAT) per 5MG
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