DIASARONE-I

DIASARONE-I

Biochem/physiol Actions

Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds to the viral 2′O methyltransferase of nonstructural protein 5 (NS5). It also decreases the DENV2-induced STAT1 phosphorylation and IFN-stimulated genes (ISGs) expression.

The antiviral effect of Diasarone-I includes half maximal effective concentration (EC50) of 4.5 ?M and half maximal cytotoxicity concentration (CC50) of >80 ?M.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576165 DIASARONE-I white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£449.89 (exc VAT) per 25MG
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3576166 DIASARONE-I white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£111.29 (exc VAT) per 5MG
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