DCPIB

DCPIB

Biochem/physiol Actions

DCPIB is a potent inhibitor of the volume-sensitive anion channel (VSAC). IC50 = 4.1µM ) versus ICl,swell in calf pulmonary artery endothelial (CPAE) cells. DCPIB does not inhibit CPAE cell ICl,Ca; hCFTR; nor guinea pig ICl,PKA, IKr, IKs,IKl, INa and ICa. DCPIB inhibition is reversible and voltage independent. ICl,swell is believed to be important in cardiovascular function. Studies have been limited by the lack of specific ligands.

DCPIB is a reversible and highly selective volume-regulated anion channel (VRAC or VSOAC) blocker (by 50/98.7% of hypotonic solution-induced Cl current or ICl,swell at 4.1/10 µM in calf pulmonary artery endothelial (CPAE) cells vs. 4.1% inhibition of Ca2+-activated ICl,Ca or CaCC at 10 µM) with little or no inhibition against hminK (IKs), hCFTR, hCLC-1/2/4/5, rCLC-K1, hKv1.5, hKv4.3, HERG (≤5.9% at 10 µM; transpected xenopus oocytes), nor IKs, IKr, IK1, INa, ICa, or ICl,PKA in isolated guinea pig cardiomyocytes. When applied in rats in vivo (10 mg/kg ip.), DCPIB is shown to protect against myocardial ischaemia/reperfusion injury.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576699 DCPIB white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£486.11 (exc VAT) per EACH
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3576700 DCPIB white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear
£119.93 (exc VAT) per EACH
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