D-NMAPPD

D-NMAPPD

Biochem/physiol Actions

D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases that suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase that elevates endogenous ceramide levels and suppress growth of cancer cells.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576200 D-NMAPPD white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£360.05 (exc VAT) per 25MG
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3576201 D-NMAPPD white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£89.14 (exc VAT) per 5MG
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