Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi

Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi

Application

The specific sites and extent of oxidation in horse cytochrome c treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

Cytochrome c is primarily known as an electron-carrying mitochondrial protein. The transition of cytochrome c between the ferrous and ferric states within the cell makes it an efficient biological electron-transporter and it plays a vital role in cellular oxidations in both plants and animals. It is generally regarded as a universal catalyst of respiration, forming an essential electron-bridge between the respirable substrates and oxygen

Other Notes

View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.

Packaging

1, 5 g in glass bottle

50, 100, 500 mg in glass bottle

Preparation Note

Prepared with acetic acid without using TCA.

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Code Description Quality Level Manufacturer Technique(s) Storage Temp. Form Assay Price Quantity
3589986 Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi 300 SIGMA-ALDRICH cell culture - mammalian: suitable −20°C powder ≥95% based on Mol. Wt. 12,384 basis, ≥95% (SDS-PAGE)
£417.86 (exc VAT) per 100MG
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3589987 Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi 300 SIGMA-ALDRICH cell culture - mammalian: suitable −20°C powder ≥95% based on Mol. Wt. 12,384 basis, ≥95% (SDS-PAGE)
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3589988 Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi 300 SIGMA-ALDRICH cell culture - mammalian: suitable −20°C powder ≥95% based on Mol. Wt. 12,384 basis, ≥95% (SDS-PAGE)
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3589989 Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi 300 SIGMA-ALDRICH cell culture - mammalian: suitable −20°C powder ≥95% based on Mol. Wt. 12,384 basis, ≥95% (SDS-PAGE)
£253.50 (exc VAT) per 50MG
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3589990 Cytochrome c from equine heart,; based on Mol. Wt. 12,384 basis, >=95% based on Mol. Wt. 12,384 basi 300 SIGMA-ALDRICH cell culture - mammalian: suitable −20°C powder ≥95% based on Mol. Wt. 12,384 basis, ≥95% (SDS-PAGE)
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