CYCLOSPORIN H

CYCLOSPORIN H

Application

Cyclosporin H has been used:to pre-culture the lineage depleted murine Flt3ITDIDH2R140Q BM cells for transductionas a formyl peptide receptor (FPR) antagonist to study the role of FPR1 in calcium mobilization in polymorphonuclear leukocytes (PMNs)as one of the small molecules to study its effect on the homology-directed repair (HDR) editing efficiency in human-induced pluripotent stem cells (iPSCs) and T cells

Biochem/physiol Actions

Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-dependent EF-2 phosphorylation.

Packaging

1, 5 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Form Assay Price Quantity
3575109 CYCLOSPORIN H white to beige 100 BQQHPBPTWWXRMU-SXHXJWHLSA-N 1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-
£156.00 (exc VAT) per 1MG
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3575110 CYCLOSPORIN H white to beige 100 BQQHPBPTWWXRMU-SXHXJWHLSA-N 1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-
£626.79 (exc VAT) per 5MG
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