CY-09

CY-09

Biochem/physiol Actions

CY-09 is an NLRP3 inflammasone inhibitor. CY-09 binds directly to the ATP-binding motif of NLRP3 NACHT domain and inhibits its ATPase activity, blocking NLRP3 inflammasome assembly and activation. In mouse models CY-09 showed therapeutic effects in type 2 diabetes and cryopyrin-associated auto-inflammatory syndrome (CAPS), which is caused by gain-of-function mutations of NLRP3.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576354 CY-09 faint yellow to dark orange SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£501.43 (exc VAT) per 25MG
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3576355 CY-09 faint yellow to dark orange SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£124.24 (exc VAT) per 5MG
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