CRIPGBM

CRIPGBM

Biochem/physiol Actions

cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC50 = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC50 = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576683 CRIPGBM white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£409.50 (exc VAT) per EACH
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3576684 CRIPGBM white to beige SIGMA-ALDRICH 2-8°C DMSO: 2 mg/mL, clear
£108.23 (exc VAT) per EACH
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