CRANAD 2

CRANAD 2

Biochem/physiol Actions

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, CRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3574159 CRANAD 2 , dark blue to black 100 SIGMA-ALDRICH 2-8°C
£552.96 (exc VAT) per 25MG
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3574160 CRANAD 2 , dark blue to black 100 SIGMA-ALDRICH 2-8°C
£160.18 (exc VAT) per 5MG
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