CEVIPABULIN FUMARATE

CEVIPABULIN FUMARATE

Biochem/physiol Actions

Cevipabulin (TTI-237) is a potent microtubule-stabilizing agent that binds to tubulin vinblastine binding site, a typical site of binding for microtubule-destabilizing agents. It is likely that cevipabulin, similarly to other triazolopyrimidines, promotes longitudinal tubulin contacts in microtubules, which promotes stabilization of micro-tubule. Cevipabulin exhibits potent cytotoxic activity in cancer cell lines including cell line expressing a high level of P-glycoprotein. It is active in vivo in several mouse xenograft models of human cancer.

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Code Description Colour Manufacturer Storage Temp. Solubility Form Assay Price Quantity
3576670 CEVIPABULIN FUMARATE white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear, H2O: 5 mg/mL
£486.11 (exc VAT) per EACH
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3576671 CEVIPABULIN FUMARATE white to beige SIGMA-ALDRICH −20°C DMSO: 2 mg/mL, clear, H2O: 5 mg/mL
£113.80 (exc VAT) per EACH
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