CD40-TRAF6 SIGNALING INHIBITOR

CD40-TRAF6 SIGNALING INHIBITOR

Application

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cellsto test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-?B).

Biochem/physiol Actions

CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.

Packaging

5, 25 mg in glass bottle

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Code Description Colour Quality Level InChI key InChI Manufacturer Solubility Form Assay Price Quantity
3574546 CD40-TRAF6 SIGNALING INHIBITOR white to beige 100 WIFPLULEUNBSTE-GZTJUZNOSA-N 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+ SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£438.75 (exc VAT) per 25MG
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3574547 CD40-TRAF6 SIGNALING INHIBITOR white to beige 100 WIFPLULEUNBSTE-GZTJUZNOSA-N 1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+ SIGMA-ALDRICH DMSO: 20 mg/mL, clear powder ≥98% (HPLC)
£138.73 (exc VAT) per 5MG
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