Carbonic Anhydrase Isozyme II from bovine erythrocytes, lyophilized powder, >=3,000 W-A units/mg pro

Carbonic Anhydrase Isozyme II from bovine erythrocytes, lyophilized powder, >=3,000 W-A units/mg pro

Application

Carbonic anhydrase from sigma has been used for the analysis of thermodynamic stability of the enzyme by measuring the binding affinity and stoichiometry. The enzyme has also been used to generate CD4+ T cell lines specific for carbonic anhydrase during the study of autoimmune pancreatitis in rat.

Biochem/physiol Actions

Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in many physiological and pathological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, inhibitors that block this enzyme can have therapeutic implications in glaucoma, epilepsy and Parkinson?s disease.

Unit Definition

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

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Code Description Quality Level Manufacturer Storage Temp. Form Price Quantity
3579141 Carbonic Anhydrase Isozyme II from bovine erythrocytes, lyophilized powder, >=3,000 W-A units/mg pro 300 SIGMA-ALDRICH −20°C lyophilized powder
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3579142 Carbonic Anhydrase Isozyme II from bovine erythrocytes, lyophilized powder, >=3,000 W-A units/mg pro 300 SIGMA-ALDRICH −20°C lyophilized powder
£814.29 (exc VAT) per 25MG
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3579143 Carbonic Anhydrase Isozyme II from bovine erythrocytes, lyophilized powder, >=3,000 W-A units/mg pro 300 SIGMA-ALDRICH −20°C lyophilized powder
£259.21 (exc VAT) per 5MG
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