Carbonic Anhydrase I from human erythrocytes,

Carbonic Anhydrase I from human erythrocytes,

Application

Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). Chaperone-like ?-crystallin binds to this state of the enzyme and prevents its aggregation. The enzyme from sigma has been used for the analysis of thermodynamic stability of the enzyme. Furthermore, its clinical significance has been evaluated in human non-small cell lung cancer.

Biochem/physiol Actions

Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in various pathologies such as glaucoma, epilepsy and Parkinson’;s disease.

Packaging

1, 5, 25 mg in glass bottle

Preparation Note

chromatographicallypurified.

Unit Definition

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

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Code Description Colour Quality Level Manufacturer Storage Temp. Form Price Quantity
3579202 Carbonic Anhydrase I from human erythrocytes, white 200 SIGMA-ALDRICH −20°C powder
£122.55 (exc VAT) per 1MG
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3579203 Carbonic Anhydrase I from human erythrocytes, white 200 SIGMA-ALDRICH −20°C powder
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3579204 Carbonic Anhydrase I from human erythrocytes, white 200 SIGMA-ALDRICH −20°C powder
£382.71 (exc VAT) per 5MG
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