Calpastatin Peptide Ac 184-210, >=95% (HPLC)

Amino Acid Sequence

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Application

Calpastatin Peptide Ac 184-210 has been used as the endogenous calpain inhibitor to study its effects on myristoylated alanine-rich C kinase substrate (MARCKS) cleavage in mouse kidney cells. It has also been used as a calpain inhibitor to examine its effects on the formation of DNA-platinum adducts by cisplatin (CDDP) in neuronal cells.

Biochem/physiol Actions

Calpastatin, located in the cytosol, is involved in selective protein cleavage in response to calcium signaling.

Calpastatin, a component of the calpain/calpastatin system, is a calpain (calcium-dependent cysteine protease) inhibitor. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation.

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Code Description Manufacturer Composition Storage Temp. Form Assay Price Quantity
3592336 Calpastatin Peptide Ac 184-210, >=95% (HPLC) SIGMA-ALDRICH Peptide Content, ≥75% −20°C lyophilized
£714.54 (exc VAT) per 1MG
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3592337 Calpastatin Peptide Ac 184-210, >=95% (HPLC) SIGMA-ALDRICH Peptide Content, ≥75% −20°C lyophilized
£420.64 (exc VAT) per 500UG
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