Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE)

Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE)

Application

Calmodulin bovine has been used inin vitro phosphorylation assay of recombinant retinoic acid-inducible gene I protein. It has also been used in the endoprotease Glu-C proteolysis and deamidation studies.

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP-ribose and is involved in intracellular Ca2+ homeostasis.

Calmodulin from bovine undergoes conformational changes upon calcium binding. It binds to sphingosylphosphorylcholine and inhibit calcineurin and phosphodiesterase enzymes.

General description

Calmodulin from bovine takes up a dumb-bell-structure. Two calciumbinding EF hand loops, antiparallel ?-sheet and three ?-helices comprises a lobe. It has a central helix connecting the lobes. Calmodulin can bind four calcium molecules in a cooperative interaction pattern.

Physical properties

Sequence:MGSSHHHHHHSSGLVPRGSHMADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Preparation Note

Produced using animal component-free materials.

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Code Description Quality Level Manufacturer Composition Form Assay Price Quantity
3589909 Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE) 200 SIGMA-ALDRICH Protein, ≥85% lyophilized powder ≥98% (SDS-PAGE)
£133.58 (exc VAT) per 0.2MG
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3589910 Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE) 200 SIGMA-ALDRICH Protein, ≥85% lyophilized powder ≥98% (SDS-PAGE)
£267.43 (exc VAT) per EACH
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3589911 Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE) 200 SIGMA-ALDRICH Protein, ≥85% lyophilized powder ≥98% (SDS-PAGE)
£445.71 (exc VAT) per 1MG
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3589912 Calmodulin bovine, recombinant, expressed in E. coli, lyophilized powder, >=98% (SDS-PAGE) 200 SIGMA-ALDRICH Protein, ≥85% lyophilized powder ≥98% (SDS-PAGE)
£905.36 (exc VAT) per 2MG
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