Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology

Descriptions

Application

Suitable for molecular biology studies of secretory proteins and mechanisms of intracellular transport

Biochem/physiol Actions

Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

General description

Brefeldin induces ADP-ribosylation of CtBP1/BARS protein that regulates the intracellular trafficking and movement of secretory proteins from endoplasmic reticulum to Golgi apparatus.

Chemical structure: macrolide

Packaging

5, 25 mg in glass bottle

Principle

Brefeldin is a fungal metabolite that disrupts protein secretion in eukaryotic cells by disrupting the Golgi apparatus. It does not affect the process of protein synthesis.

Specifications

No detailed specifications are available for this product.

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Code	Description	InChI key	InChI	Manufacturer	Form	Assay	Price		Quantity
3581824	Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology	KQNZDYYTLMIZCT-KQPMLPITSA-N	1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1	SIGMA-ALDRICH	powder	≥99% (HPLC and TLC)	£930.43 (exc VAT) per 25MG		- +
3581825	Brefeldin A, >=99% (HPLC and TLC), BioXtra, for molecular biology	KQNZDYYTLMIZCT-KQPMLPITSA-N	1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1	SIGMA-ALDRICH	powder	≥99% (HPLC and TLC)	£285.54 (exc VAT) per 5MG		- +